Pan-transcriptome

Why in News?

• Researchers at the University of California, Santa Cruz, have recently proposed a “Pan-transcriptome” which combines a transcriptome and a pan-genome.

Highlights

• Mapping transcriptome (complete set of RNA molecules) allows researchers to better understand an individual’s gene expression
• Pan-transcriptome is a reference that contains genetic material from a cohort of diverse individuals, rather than just a single linear strand.
• The pan-transcriptome builds on the emerging concept of “pan-genomics” in the genomics field.
• Typically, when evaluating an individual’s genomic data for variation, scientists compare the individual’s genome to that of a reference made up of a single linear strand of DNA bases.
• A “pan-transcriptome” is a combination of a transcriptome and a pan-genome.
• A transcriptome is the complete set of RNA molecules in a cell or tissue including mRNA, rRNA, tRNA, and other non-coding RNA, that are produced by the genetic material of an organism.
• It Is the complement of the genome, which is the entire set of genetic material in an organism.
• Pan-transcriptome is a reference that contains genetic material from a cohort of diverse individuals, rather than just a single linear strand.
• The pan-transcriptome builds on the emerging concept of “pan-genomics” in the genomics field.
• Typically, when evaluating an individual’s genomic data for variation, scientists compare the individual’s genome to that of a reference made up of a single linear strand of DNA bases.
• A “pan-transcriptome” is a combination of a transcriptome and a pan-genome.